ACTN3 R577X Polimorfizminin Atletik Performasyondaki Önemi ve R577X Mutant Tip ve Wild Tip ACTN3 Proteininin Biyoinformatik Analizi ile Modellemesi
نویسندگان
چکیده
منابع مشابه
ACTN3 R577X Polymorphism and Neuromuscular Response to Resistance Training.
The R577X polymorphism at the ACTN3 gene has been associated with muscle strength, hypertrophy and athletic status. The X allele, which is associated with the absence of ACTN3 protein is supposed to impair performance of high force/velocity muscle contractions. The purpose of the present study was to investigate the association of the R577X polymorphism with the muscle response to resistance tr...
متن کاملACTN3 (R577X) genotype is associated with fiber type distribution.
alpha-Actinin-3 is a Z-disc structural protein found only in type II muscle fibers. The X allele of the R577X polymorphism in the ACTN3 gene results in a premature stop codon and alpha-actinin-3 deficiency in XX homozygotes. Associations between the R577X polymorphism and the muscle-power performance of elite athletes have been described earlier. About 45% of the fiber type proportions are dete...
متن کاملThe ACTN3 R577X variant in sprint and strength performance
PURPOSE The aim of this study is to examine the association between the distribution of ACTN3 genotypes and alleles in power, speed, and strength-oriented athletics. METHODS ACTN3 genotyping was carried out for a total of 975 Korean participants: top-level sprinters (n = 58), top-level strength athletes (n = 63), and healthy controls (n = 854). RESULTS Genetic associations were evaluated by...
متن کاملThe ACTN3 R577X polymorphism in East and West African athletes.
PURPOSE To determine the frequency of the ACTN3 R577X polymorphism (functional R allele and nonfunctional X allele) in a variety of African populations and to examine its influence on the success of elite East African endurance runners and West African sprinters. METHODS The R577X polymorphism was genotyped in 198 Ethiopian controls and 76 elite Ethiopian endurance athletes, 158 Kenyan contro...
متن کاملACTN3 R577X genotypes associate with Class II and deepbite malocclusions.
INTRODUCTION α-Actinins are myofibril anchor proteins that influence the contractile properties of skeletal muscles. ACTN2 is expressed in slow type I and fast type II fibers, whereas ACTN3 is expressed only in fast fibers. ACTN3 homozygosity for the 577X stop codon (ie, changing 577RR to 577XX, the R577X polymorphism) results in the absence of α-actinin-3 in about 18% of Europeans, diminishes ...
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ژورنال
عنوان ژورنال: Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
سال: 2021
ISSN: 2587-0874
DOI: 10.51754/cusbed.880707